DOI
10.1016/j.jds.2011.09.004
First Page
205
Last Page
209
Abstract
Abstract Background/purpose Oral squamous cell carcinoma (OSCC) is highly prevalent worldwide. Lysyl oxidase (LOX) is an important enzyme that modulates the extracellular matrix. The LOX superfamily contains LOX and LOX-like (LOXL) enzymes. The aim of the present study was to determine the expressions of LOXL genes in OSCC. Materials and methods RT-PCR was performed to detect messenger (m)RNA expression of the LOXL genes, LOX-L1 , -L3 , and -L4 , in paired OSCC and non-cancerous matched tissues (NCMTs). Results Increased mRNA expressions of LOX-L1 and LOX-L3 in OSCC relative to NCMTs were identified in 41% and 65% of OSCC samples, respectively. The normalized mRNA expression of LOXL-3 was 1.11 ± 0.15 in OSCC, which was significantly higher than 0.68 ± 0.12 in NCMTs (P = 0.004). The increased expression of LOX-L3 was associated with worse survival of OSCC patients (P = 0.028). Conclusion The results indicated the frequent increase in LOX-L3 mRNA expression in OSCC, and the value of LOX-L3 mRNA expression might have clinical uses in monitoring OSCC.
Recommended Citation
Shieh, Tzong-Ming; Ko, Shun-Yao; Chang, Shu-Shin; Chang, Kuo-Wei; Shih, Yin-Hua; and Liu, Chung-Ji
(2011)
"Lysyl oxidase-like 3 mRNA expression indicates poor survival from oral squamous cell carcinoma,"
Journal of Dental Sciences: Vol. 6:
Iss.
4, Article 6.
DOI: 10.1016/j.jds.2011.09.004
Available at:
https://jds.ads.org.tw/journal/vol6/iss4/6
