Developing anti-inflammatory mineral trioxide aggregate as dental implant crown cement to reduce peri-implantitis incidence

Authors

• Yung-Fu Hsu, Department of Materials and Mineral Resources Engineering, National Taipei University of Technology, Taipei, Taiwan.
• Sea-Fue Wang, Department of Materials and Mineral Resources Engineering, National Taipei University of Technology, Taipei, Taiwan.
• Yi-Le Liao, Department of Materials and Mineral Resources Engineering, National Taipei University of Technology, Taipei, Taiwan.
• Chih-Sheng Lin, Yes Dental clinic, Taipei, Taiwan.
• Ssu-Chi Chen, Department of Materials and Mineral Resources Engineering, National Taipei University of Technology, Taipei, Taiwan.
• Sheng-Yang Lee, School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
• Wei-Chun Lin, Department of Dentistry, Wan Fang Hospital, Taipei Medical University, Taipei, TaiwanFollow

First Page

1459

Last Page

1468

Abstract

背景/目的：牙周組織周圍的牙科樹脂黏固劑殘留是植體周圍炎的原因之一。嚴重病例可能導致植體鬆動或脫落。因此，本研究旨在對礦物三氧化物聚集體（MTA）進行改性，使其成為一種抗發炎的牙科植體冠黏固劑（ICC）。

材料與方法：本研究評估了去離子水溶液（Daq）、羥基磷灰石溶液（Haq）和氯化鈣溶液（Caq）對ICC凝固時間、抗壓強度、黏結強度和生物相容性的影響。以單因子變異數分析（ANOVA）檢定各實驗組間的差異（ P < 0.05）。

結果：表面微觀結構分析表明，添加Haq和Caq有助於ICC顆粒間的結合。表面元素分析表明，添加Haq增加了Ca離子含量。凝固時間結果表明，與Daq相比，Caq和Haq分別使最終凝固時間縮短了46.5%和34.7%（ P < 0.05）。 Caq的抗壓強度分別比Daq和Haq高35.1%和13.4%（ P < 0.05）。三種ICC組的黏接強度結果表明，樹脂黏接劑的效果相同（ P > 0.05）。生物相容性和清除活性測試表明，ICC優於樹脂黏接劑。

結論： ICC與Caq合併使用可縮短凝固時間、提高抗壓強度、增強生物相容性並降低發炎發生的可能性。因此，ICC與Caq聯合使用可作為牙科樹脂黏固劑的替代方案。

Recommended Citation

Hsu, Yung-Fu; Wang, Sea-Fue; Liao, Yi-Le; Lin, Chih-Sheng; Chen, Ssu-Chi; Lee, Sheng-Yang; and Lin, Wei-Chun (2026) "Developing anti-inflammatory mineral trioxide aggregate as dental implant crown cement to reduce peri-implantitis incidence," Journal of Dental Sciences: Vol. 21: Iss. 3, Article 14.
Available at: https://jds.ads.org.tw/journal/vol21/iss3/14

Publication Date

2026