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DOI

10.1016/j.jds.2024.01.012

First Page

1087

Last Page

1095

Abstract

Abstract Background/purpose Healthy states of human microbiota depend on a stable community of symbiotic microbes irrespective of external challenges from the environment. Thus, long-term stability of the oral microbiota is of importance, particularly for older patient populations. Materials and methods We used next-generation sequencing (NGS) to examine the tongue microbiota of 18 individuals receiving long-term care over a 10-month period. Results Beta diversity analysis demonstrated temporal stability of the tongue microbiota, as microbial compositions from all time points were indistinguishable from each other ( P = 0.0887). However, significant individual variation in microbial composition ( P = 0.0001) was observed, underscoring the presence of a unique microbial profile for each patient. Conclusion The temporal dynamics of tongue microbiota exhibit long-term stability, providing diagnostic implications for oral diseases within older patient populations.

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