DOI
10.1016/j.jds.2023.08.019
First Page
652
Last Page
655
Abstract
Abstract Few studies have investigated the mucosal immune response after BNT162b2-booster vaccination in individuals with periodontitis. In this study, we evaluated the persistence of IgA anti-SARS-CoV-2-N-protein in saliva and gingival crevicular fluid (GCF) of patients with periodontitis for at least six months post BNT162b2 vaccine booster. We included patients with moderate (n = 7) and severe (n = 7) periodontitis and participants without periodontitis (n = 7) as controls. The Bradford method measured the protein concentrations in the samples, and an enzyme-linked immunosorbent assay of the SARS-CoV-2 N protein was performed to analyze the targeted IgA level. For the tested SARS-CoV-2 antigen (N-protein), IgA levels in saliva and GCF showed a strong and significant correlation. Therefore, in patients with moderate or severe periodontitis, saliva and GCF can provide information regarding the IgA response against SARS-CoV-2-N-protein. The neutralizing activity of IgA against SARS-CoV-2 was not investigated in this study, necessitating further research.
Recommended Citation
Bachtiar, Boy M.; Bachtiar, Endang; Soeroso, Yuniarti; Haerani, Natalina; Isamah, Nada; and Cahyani, Esti
(2024)
"Immunoglobulin A response to SARS-CoV-2-N-protein potentially persists in oral fluids of patients with periodontitis six months after mRNA vaccine administration,"
Journal of Dental Sciences: Vol. 19:
Iss.
1, Article 61.
DOI: 10.1016/j.jds.2023.08.019
Available at:
https://jds.ads.org.tw/journal/vol19/iss1/61
