A potential reciprocal emergence of regulatory T cells in oral lichen planus and pemphigus vulgaris: A meta-analysis

Authors

Xuemin Shen, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People's Hospital
Wei Liu, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People's Hospital
Qianqian Zhang, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People's Hospital
Zhexuan Bao, Guangzhou Medical University

DOI

10.1016/j.jds.2022.07.009

First Page

437

Last Page

442

Abstract

Abstract Oral lichen planus (OLP) and pemphigus vulgaris (PV) are 2 common inflammatory mucocutaneous diseases of immune-based etiology. Evidence indicates regulatory T (Treg) cells maybe play a role in the pathogenesis of OLP and PV, which are caused by aberrant immune responses. In this report, 7 eligible case–control studies containing 517 OLP patients and 261 healthy controls (HC) were identified. The level of Tregs was significantly higher in OLP patients than HC (mean difference: 1.79; 95%CI: 0.99, 2.60). On the other hand, 7 eligible case–control studies containing 169 PV patients and 121 HC were identified. Conversely, the level of Tregs was significantly lower in PV patients than HC (mean difference: −2.49; 95%CI: −3.90, −1.08). Collectively, this analysis for the first time reported reciprocal emergence of Tregs in OLP and PV using meta-analysis, and provided an interesting insight into a previously undescribed the linkage of the 2 mucocutaneous diseases.

Recommended Citation

Shen, Xuemin; Liu, Wei; Zhang, Qianqian; and Bao, Zhexuan (2023) "A potential reciprocal emergence of regulatory T cells in oral lichen planus and pemphigus vulgaris: A meta-analysis," Journal of Dental Sciences: Vol. 18: Iss. 1, Article 45.
DOI: 10.1016/j.jds.2022.07.009
Available at: https://jds.ads.org.tw/journal/vol18/iss1/45