DOI
10.1016/j.jds.2019.01.002
First Page
192
Last Page
197
Abstract
Abstract Background/purpose The purpose of this study was to investigate whether poly-gamma-glutamic acid (γ-PGA), a naturally derived biomaterial, was suitable as an alternative antibacterial mouthwash in the absence of alcohol. Materials and methods Three bacterial strains, Escherichia coli , Staphylococcus aureus , and Pseudomonas aeruginosa , were used for testing the antibacterial activity of mouthwashes. In addition, cell viability, cytotoxicity, and genotoxicity experiments were conducted for testing the toxicity of mouthwashes. Results We demonstrated that 10000 ppm of γ-PGA without alcohol could efficiently inhibit 99% of bacterial growth. In addition, γ-PGA did not cause any cytotoxicity or genotoxicity. Conclusion 10000 ppm of γ-PGA in an alcohol-free mouthwash is an alternative biomaterial for mouthwashes.
Recommended Citation
Su, Chen-Ying; Chen, Chia-Chun; Chen, Hsuan-Yu; Lin, Chun-Pin; Lin, Feng-Huei; and Fang, Hsu-Wei
(2019)
"Characteristics of an alternative antibacterial biomaterial for mouthwash in the absence of alcohol,"
Journal of Dental Sciences: Vol. 14:
Iss.
2, Article 21.
DOI: 10.1016/j.jds.2019.01.002
Available at:
https://jds.ads.org.tw/journal/vol14/iss2/21
