DOI
10.1016/j.jds.2015.04.001
First Page
338
Last Page
340
Abstract
Abstract The purpose of this study was to determine the cytotoxicity of the zinc-oxide eugenol-based root-canal sealer Canals on murine immortalized cementoblast cell line. Cytotoxicity judged by the alamarBlue assay demonstrated that Canals exhibited cytotoxicity to cementoblasts in a dose-dependent manner (P < 0.05). The apoptotic cell death via caspase activation was evaluated by fluorometric assay. Canals was found to stimulate caspase-3, -8, and -9 activities in a dose-dependent manner (P < 0.05). In summary, the cytotoxicity of Canals occurs through apoptosis by the activation of caspases in cementoblasts.
Recommended Citation
Huang, Fu-Mei; Kuan, Yu-Hsiang; Lee, Shiuan-Shinn; and Chang, Yu-Chao
(2015)
"Caspase activation by a zinc-oxide eugenol-based root-canal sealer in cementoblasts,"
Journal of Dental Sciences: Vol. 10:
Iss.
3, Article 17.
DOI: 10.1016/j.jds.2015.04.001
Available at:
https://jds.ads.org.tw/journal/vol10/iss3/17
